Description
The Human miRNA Tissue Atlas is a
catalog of tissue-specific microRNA (miRNA) expression across 62 tissues. This track contains
quantile normalized miRNA expression data sampled from two individuals and mapped to
miRBase v21 coordinates. The track contains two subtracks, one
for each individual sampled.
The Tissue Specificity Index (TSI) is analogous to the "tau" value for mRNA expression,
and is calculated as described in the
associated publication. Values closer to 0 indicate miRNAs expressed in many or all tissues,
while values closer to 1 indicate miRNAs expressed only in a specific tissue or tissues. To
browse miRNAs by TSI value, please see the
miRNA Tissue Atlas.
Display Conventions and Configuration
This track is formatted as a barChart track,
similar to the GTEx or the
TCGA Cancer Expression tracks, where the
heights of each bar indicate the expression value for the miRNA in a specific tissue. The tissues
sampled are described in the table below:
| Bar Color | Sample 1 | Sample 2 |
| Adipocyte | Adipocyte |
| Artery | Artery |
| Colon | Colon |
| Dura mater | Dura mater |
| Kidney | Kidney |
| Liver | Liver |
| Lung | Lung |
| Muscle | Muscle |
| Myocardium | Myocardium |
| Skin | Skin |
| Spleen | Spleen |
| Stomach | Stomach |
| Testis | Testis |
| Thyroid | Thyroid |
| Small intestine | |
| Bone | |
| Gallbladder | |
| Fascia | |
| Bladder | |
| Epididymis | |
| Tunica albuginea | |
| Nervus intercostalis | |
| Arachnoid mater | |
| Brain | |
| | Small intestine duodenum |
| | Small intestine jejunum |
| | Pancreas |
| | Kidney glandula suprarenalis |
| | Kidney cortex renalis |
| | Esophagus |
| | Prostate |
| | Bone marrow |
| | Vein |
| | Lymph node |
| | Nerve not specified |
| | Pleura |
| | Pituitary gland |
| | Spinal cord |
| | Thalamus |
| | Brain white matter |
| | Nucleus caudatus |
| | Kidney medulla renalis |
| | Brain gray_matter |
| | Cerebral cortex temporal |
| | Cerebral cortex frontal |
| | Cerebral cortex occipital |
| | Cerebellum |
The 14 shared tissues sampled across both individuals are presented in the same order for easier comparison.
Data Access
The underlying expression matrix and TSI values can be obtained from the
miRNA tissue atlas website, in the
data_matrix_quantile.txt and tsi_quantile.csv files.
References
Ludwig N, Leidinger P, Becker K, Backes C, Fehlmann T, Pallasch C, Rheinheimer S, Meder B,
Stähler C, Meese E et al.
Distribution of miRNA expression across human tissues.
Nucleic Acids Res. 2016 May 5;44(8):3865-77.
PMID: 26921406; PMC: PMC4856985
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